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Immunogen sequence: SFWTNMEKLM DHIYAVCGQV QHLQKVLAKK RDPVSHICFI EEIVKDGQPE IFYTFWNSVT QALSSQFHMA TNSSMFLKQA FEGEYPKLLR LYNDLWKRLQ QYSQHIQGNF NASGTTDLYV D
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.
COG5 is required for normal Golgi function.Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002 [PubMed 11980916]).[supplied by OMIM].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 13S golgi transport complex 1 90 kDa subunit; 13S Golgi transport complex 90 kDa subunit; COG complex subunit 5; Component of oligomeric Golgi complex 5; conserved oligomeric Golgi complex protein 5; Conserved oligomeric Golgi complex subunit 5; Golgi transport complex 1; GTC-90
Gene Aliases: CDG2I; COG5; GOLTC1; GTC90
UniProt ID: (Human) Q9UP83
Entrez Gene ID: (Human) 10466
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