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Product Details
PA5-59147
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RAPGEF3. Recombinant protein control fragment (Product #RP-97655).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2646308
Product Specific Information
Immunogen sequence: LAVEDSPALG APRVGALPDV VPEGTLLNMV LRRMHRPRSC SYQLLLEHQR PSCIQGLRWT PLTNSEESLD FSESLEQAST ERVLRAGRQL HRHLLATCPN L
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 77%.
Target Information
Gene ontology (GO) annotation includes small GTPase mediated signal transduction. Target protein binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 9330170P05Rik; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; EPAC 1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Gene Aliases: bcm910; CAMP-GEFI; CGEF1; EPAC; EPAC1; HSU79275; RAPGEF3
UniProt ID: (Human) O95398
Entrez Gene ID: (Human) 10411
angiogenesis
signal transduction
brain development
cell proliferation
negative regulation of cardiac muscle cell apoptotic process
positive regulation of smooth muscle cell migration
cAMP-mediated signaling
spinal cord development
positive regulation of cAMP catabolic process
Rap protein signal transduction
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
negative regulation of syncytium formation by plasma membrane fusion
response to nicotine
cellular response to drug
positive regulation of GTPase activity
positive regulation of angiogenesis
positive regulation of cell size
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein export from nucleus
regulation of insulin secretion
positive regulation of stress fiber assembly
positive regulation of syncytium formation by plasma membrane fusion
artery development
establishment of endothelial barrier
cellular response to cAMP
cellular response to transforming growth factor beta stimulus
liver regeneration
positive regulation of protein acetylation
positive regulation of GTP binding
positive regulation of calcium ion transmembrane transport
positive regulation of hydrogen:potassium-exchanging ATPase activity
cellular response to L-dopa
dorsal root ganglion development
regulation of actin cytoskeleton reorganization
positive regulation of actin cytoskeleton reorganization
regulation of histone H3-K9 acetylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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