Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
alanyl-tRNA Synthetase Polyclonal Antibody
Product Details
PA5-59335
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human alanyl-tRNA Synthetase. Recombinant protein control fragment (Product #RP-98616).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637831
Product Specific Information
Immunogen sequence: DRASKADVQK RVLEKTKQFI DSNPNQPLVI LEMESGASAK ALNEALKLFK MHSPQTSAML FTVDNEAGKI TCLCQVPQNA ANRGLKASEW VQQVSGLMDG KGGGKD
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
Target Information
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E. coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: AARS; alanine tRNA ligase 1, cytoplasmic; Alanine--tRNA ligase, cytoplasmic; alanine--tRNA ligase, cytoplasmic {ECO:0000255|HAMAP-Rule:MF_03133}; Alanyl-tRNA synthetase; alanyl-tRNA synthetase {ECO:0000255|HAMAP-Rule:MF_03133}; alanyl-tRNA synthetase, cytoplasmic; AlaRS; alaRS {ECO:0000255|HAMAP-Rule:MF_03133}; Protein lactyltransferase AARS1; Protein sticky; Renal carcinoma antigen NY-REN-42; Sti
Gene Aliases: AARS; AARS1; AI316495; C76919; CMT2N; EIEE29; sti
UniProt ID: (Human) P49588, (Mouse) Q8BGQ7, (Rat) P50475
Entrez Gene ID: (Human) 16, (Mouse) 234734, (Rat) 292023
tRNA binding
aminoacyl-tRNA editing activity
alanine-tRNA ligase activity
ATP binding
zinc ion binding
amino acid binding
nucleotide binding
nucleic acid binding
RNA binding
aminoacyl-tRNA ligase activity
protein binding
ligase activity
ligase activity, forming aminoacyl-tRNA and related compounds
metal ion binding
aminoacyl-tRNA synthetase
hair follicle development
tRNA modification
tRNA aminoacylation for protein translation
alanyl-tRNA aminoacylation
regulation of translational fidelity
protein folding
tRNA processing
cerebellar Purkinje cell layer development
endoplasmic reticulum unfolded protein response
response to amino acid
negative regulation of neuron apoptotic process
neuromuscular process controlling balance
translation
cellular response to unfolded protein
tRNA aminoacylation
skin development
neuromuscular process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support