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Invitrogen
FLRG Polyclonal Antibody
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Product Details
PA5-60983
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FLRG. Recombinant protein control fragment (Product #RP-100061).
Conjugate
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2641668
Product Specific Information
Immunogen sequence: MGSGNPAPGG VCWLQQGQEA TCSLVLQTDV TRAECCASGN IDTAWSNLTH PGNKINLLGF LGLVHCLPCK DSCDG
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.
Target Information
Follistatin-like 3 (FSTL3) is a gene located on chromosome 19p13.3 and encodes a secreted glycoprotein that belongs to the follistatin-related protein family. FSTL3 functions as an antagonist to members of the transforming growth factor-beta (TGF-ß) superfamily, particularly inhibiting activin and myostatin signaling. This inhibitory action is crucial for regulating muscle growth, fertility, and inflammation. FSTL3 is expressed in various tissues, including the placenta, gonads, and skeletal muscle, where it modulates physiological processes by binding to and neutralizing the activities of its target ligands. Dysregulation of FSTL3 has been implicated in conditions such as muscle wasting, metabolic syndrome, and reproductive disorders, reflecting its role in maintaining tissue homeostasis and function. Research into FSTL3 focuses on its potential therapeutic applications in diseases involving TGF-ß pathway dysregulation, offering insights into strategies for modulating growth factor activities in clinical settings.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLRGFSRP; follistatin-like 3 (secreted glycoprotein); Follistatin-like protein 3; Follistatin-related gene protein; Follistatin-related protein 3
Gene Aliases: FLRG; FSRP; FSTL3; UNQ674/PRO1308
UniProt ID: (Human) O95633
Entrez Gene ID: (Human) 10272
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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