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Product Details
PA5-63473
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Lymphotactin. Recombinant protein control fragment (Product #RP-104515).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2643623
Product Specific Information
Immunogen sequence: VCADPQATWV RDVVRSMDRK SNTRNNMIQT KPTGTQQSTN TAVTLTG
Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 40%.
Target Information
Lymphotactin, otherwise known as XCL1, is a member of the C-chemokine family that uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation. Lymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATAC; C motif chemokine 1; chemokine (C motif) ligand 1; Cytokine SCM-1; Lymphotactin; Lymphotaxin; SCM-1-alpha; SCM-1-beta; SCM-1alpha; SCM-1beta; SCM1alpha; SCM1beta; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); Small-inducible cytokine C1; XC chemokine ligand 1
Gene Aliases: ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1; SCM1A; SCYC1; XCL1
UniProt ID: (Human) P47992
Entrez Gene ID: (Human) 6375
positive regulation of T cell mediated cytotoxicity
monocyte chemotaxis
positive regulation of leukocyte chemotaxis
negative regulation of T cell cytokine production
positive regulation of T cell cytokine production
negative regulation of T-helper 1 type immune response
signal transduction
G-protein coupled receptor signaling pathway
cell-cell signaling
response to virus
positive regulation of T cell chemotaxis
neutrophil chemotaxis
negative regulation of interferon-gamma production
negative regulation of interleukin-2 production
positive regulation of interleukin-10 production
mature natural killer cell chemotaxis
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of GTPase activity
negative regulation of transcription, DNA-templated
regulation of inflammatory response
positive regulation of inflammatory response
release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to interleukin-4
cellular response to tumor necrosis factor
cellular response to transforming growth factor beta stimulus
positive regulation of transforming growth factor beta production
positive regulation of granzyme B production
positive regulation of neutrophil chemotaxis
positive regulation of thymocyte migration
positive regulation of natural killer cell chemotaxis
positive regulation of granzyme A production
negative regulation of T-helper 1 cell activation
positive regulation of B cell chemotaxis
positive regulation of T-helper 2 cell cytokine production
positive regulation of T-helper 1 cell cytokine production
positive regulation of immunoglobulin production in mucosal tissue
negative regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD8-positive, alpha-beta T cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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