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Immunogen sequence: RVLVHTSVSP SPDNLRRFAL EHEASDLVEI YLWKLVKGIF HLTQIKKVRK QDFQKEAQHF RLLAGPHEGH WNVFLAQTLE LKVTASPDKV TKT
CHRDL2 encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BNF-1; Breast tumor novel factor 1; chordin-like 2; Chordin-like protein 2; Chordin-related protein 2; FKSG37
Gene Aliases: BNF1; CHL2; CHRDL2; UNQ765/PRO1557
UniProt ID: (Human) Q6WN34
Entrez Gene ID: (Human) 25884
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