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Immunogen sequence: PQHCLKEEEL ERKPSLSLTL TLGEADHNHY GYPHSS
Highest antigen sequence indentity to the following orthologs: Mouse - 47%, Rat - 50%.
Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG). Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Lipid phosphate phosphohydrolase 2; LPR3; PAP-2c; PAP2-G; PAP2-gamma; PAP2c; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c; phosphatidic acid phosphatase type 2C; phosphatidic acid phosphohydrolase type 2c; Phospholipid phosphatase 2; PRG-2; PRG2; type-2 phosphatidic acid phosphatase-gamma
Gene Aliases: LPP2; PAP-2c; PAP2-g; PLPP2; PPAP2C
UniProt ID: (Human) O43688
Entrez Gene ID: (Human) 8612
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