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Invitrogen
ACVR2A Polyclonal Antibody
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Application
FIGURE: 1 / 5
ACVR2A Antibody (PA5-96020) in ICC/IF
Immunofluorescence analysis of ACVR2A in NIH/3T3 cells. Samples were incubated with ACVR2A Polyclonal antibody (Product # PA5-96020) using a dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
Product Details
PA5-96020
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-140 of human ACVR2A (NP_0016071)
Conjugate
Unconjugated
Form
Liquid
Concentration
1.44 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807822
Product Specific Information
Positive Samples: SW480, Mouse kidney, Rat testis, Rat ovary; Cellular Location: Membrane, Single-pass type I membrane protein
Immunogen sequence: AILGRSETQE CLFFNANWEK DRTNQTGVEP CYGDKDKRRH CFATWKNISG SIEIVKQGCW LDDINCYDRT DCVEKKDSPE VYFCCCEGNM CNEKFSYFPE MEVTQPTSNP VTPKPPYYNI L
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IIA; activin A receptor, type IIA; activin receptor IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA; type II activin receptor
Gene Aliases: ACTRII; ActrIIa; ACVR2; ACVR2A; rActR-II; TactrII
UniProt ID: (Human) P27037, (Rat) P38444, (Mouse) P27038
Entrez Gene ID: (Human) 92, (Rat) 29263, (Mouse) 11480
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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