TheraPure™ GMP Nucleotides

Access to customized raw materials for producing RNA vaccines and therapeutics. Inquire about available services.

Thermo Scientific™

TheraPure™ GMP Nucleotides

Name: TheraPure™ GMP Nucleotides
SKU: R00017SKB002

TheraPure GMP nucleotides help accelerate mRNA vaccine and therapeutics production from preclinical development to commercialization.

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Catalog Number	Product Type	Concentration	Quantity	Format
R00017SKB002	UTP, tris solution	200 mM	5 mL	Business supply
R00014SKB002	ATP, tris solution	200 mM	5 mL	Business supply
R00014SKB005	ATP, tris solution	200 mM	50 mL	Business supply
R00014SKB004	ATP, tris solution	200 mM	500 mL	Business supply
R044SKB001	ATP, sodium solution	100 mM	3.5 mL	Business supply
R044SKB002	ATP, sodium solution	100 mM	17 mL	Business supply
R0441SKB003	ATP, sodium solution	100 mM	50 mL	Business supply
R0441SKB009	ATP, sodium solution	100 mM	500 mL	Business supply
R00015SKB002	CTP, tris solution	200 mM	5 mL	Business supply
R00015SKB005	CTP, tris solution	200 mM	50 mL	Business supply
R00015SKB004	CTP, tris solution	200 mM	500 mL	Business supply
R045SKB001	CTP, sodium solution	100 mM	3.5 mL	Business supply
R045SKB002	CTP, sodium solution	100 mM	17 mL	Business supply
R0451SKB003	CTP, sodium solution	100 mM	50 mL	Business supply
R0451SKB009	CTP, sodium solution	100 mM	500 mL	Business supply
R00016SKB002	GTP, tris solution	200 mM	5 mL	Business supply
R00016SKB005	GTP, tris solution	200 mM	50 mL	Business supply
R00016SKB004	GTP, tris solution	200 mM	500 mL	Business supply
R046SKB001	GTP, sodium solution	100 mM	3.5 mL	Business supply
R046SKB002	GTP, sodium solution	100 mM	20.5 mL	Business supply
R0461SKB003	GTP, sodium solution	100 mM	50 mL	Business supply
R0461SKB009	GTP, sodium solution	100 mM	500 mL	Business supply
R00017SKB005	UTP, tris solution	200 mM	50 mL	Business supply
R00017SKB004	UTP, tris solution	200 mM	500 mL	Business supply
R047SKB001	UTP, sodium solution	100 mM	3.5 mL	Business supply
R0471SKB006	UTP, sodium solution	100 mM	20 mL	Business supply
R0471SKB002	UTP, sodium solution	100 mM	100 mL	Business supply
R0471SKB003	UTP, sodium solution	100 mM	500 mL	Business supply
R00014SKB002C	ATP, Tris Solution	200 mM	5 mL	Instant purchase
R044SKB001C	ATP, Sodium Solution	100 mM	3.5 mL	Instant purchase
R00015SKB002C	CTP, Tris Solution	200 mM	5 mL	Instant purchase
R045SKB001C	CTP, Sodium Solution	100 mM	3.5 mL	Instant purchase
R00016SKB002C	GTP, Tris Solution	200 mM	5 mL	Instant purchase
R046SKB001C	GTP, Sodium Solution	100 mM	3.5 mL	Instant purchase
R00017SKB002C	UTP, Tris Solution	200 mM	5 mL	Instant purchase
R047SKB001C	UTP, Sodium Solution	100 mM	3.5 mL	Instant purchase

36 Options

Catalog number R00017SKB002

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Product Type:

UTP, tris solution

Concentration:

200 mM

Quantity:

5 mL

Format:

Business supply

Thermo Scientific TheraPure GMP nucleoside triphosphates (NTPs) are manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. They are suitable as core building blocks for mRNA synthesis in the development and manufacturing of mRNA therapeutics. Nucleotides ATP, CTP, GTP, and UTP are available and are supplied in sodium- or Tris-titrated solutions.

Thermo Scientific TheraPure GMP* nucleoside triphosphates (NTPs) are manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. They are suitable as core building blocks for mRNA synthesis in the development and manufacturing of mRNA therapeutics. Nucleotides ATP, CTP, GTP, and UTP are available and are supplied in sodium- or Tris-titrated solutions.

Designed for process development and manufacturing

TheraPure GMP nucleotides help accelerate mRNA vaccine and therapeutics production from preclinical development to commercialization by providing:

Quality—meet critical product quality needs to accelerate therapeutic development and manufacture
Minimal risk—reduce risks in developing a therapeutic by utilizing proven products
Technical partnership—partner with expert product and technical support
Secure and consistent supply—count on a secure and stable supply of product at a global scale

Supported by unique quality system

TheraPure GMP nucleotides are supported by a comprehensive quality system and documentation, including:

Manufactured to relevant ICH Q7 GMP guidelines
Animal-origin–free (AOF) manufacturing processes, materials, and facilities
Validated manufacturing processes and analytical test methods
Comprehensive impurity profiles
Verified compendial assays where applicable
Product stability data
Tested by analytical methods following ICH Q2 guidelines whenever possible
Drug master file (DMF)

Two available formats

These two formats are offered to accommodate different mRNA manufacturing processes:

100 mM aqueous solution with Na+ titrated to pH 7.3–7.5 with NaOH
200 mM aqueous solution with Tris counterion titrated to pH 7.3–7.7 with Tris base

Modified nucleotides

TheraPure GMP N1-methylpseudo-UTP is also available.

*TheraPure GMP refers to the quality level of the raw, ancillary, or starting materials to be used for further manufacturing. TheraPure GMP products are manufactured in facilities with ISO 9001–certified quality management systems that operate in accordance with relevant good manufacturing practice (GMP) principles, as outlined in ICH Q7 or equivalent guidance documents or standards.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.

Specifications

FormatBusiness supply

pH7.3 to 7.7

Molecular Weight (g/mol)484.14 g/mol

Product TypeUTP, tris solution

Shelf LifeUp to 36 months after manufacturing when stored at –20°C

Concentration200 mM

Label or DyeUnlabeled

Purity≥99%

Quantity5 mL

Product LineTheraPure™ GMP

ColorTransparent

For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis

Unit SizeEach