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Invitrogen
Human WDR65 (aa 129-266) Control Fragment Recombinant Protein
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Product Details
RP-102002
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
PESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTLKQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKSLDVIQESESLIEFPPVSSPLP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (78%), Rat (78%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-51738. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The WDR65 gene, which stands for WD Repeat Domain 65, encodes a protein characterized by the presence of WD repeat domains that facilitate protein-protein interactions. This gene is implicated in the assembly of a subset of inner arm dyneins, critical for ciliary motility and axonemal structure. Mutations in WDR65 have been associated with diseases such as Van der Woude syndrome (VWS) and related craniofacial disorders, highlighting its role in developmental processes. Specifically, a missense mutation in WDR65 was identified as a potential cause of VWS, suggesting that WDR65 is a target for regulatory factors like IRF6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cilia- and flagella-associated protein 57; WD repeat-containing protein 65
Gene Aliases: CFAP57; VWS2; WDR65
UniProt ID: (Human) Q96MR6
Entrez Gene ID: (Human) 149465
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