Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
Highest antigen sequence indentity to the following orthologs: Mouse (51%), Rat (51%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58967. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL2 has three conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain and a Lin11, Isl-1 and Mec-3 (LIM) domain. It has been demonstrated that MICAL2 could regulate actin stress fibers and is required for normal actin organization. In addition, MICAL2-PV, a novel splicing variants of MICAL2, has been reported to be involved in cancer progression of prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: [F-actin]-monooxygenase MICAL2; flavoprotein oxidoreductase MICAL2; MICAL C-terminal-like protein; MICAL-2; Mical-cL; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2
Gene Aliases: KIAA0750; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; MICALCL
UniProt ID: (Human) Q7Z3A8
Entrez Gene ID: (Human) 9645
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