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Highest antigen sequence indentity to the following orthologs: Mouse (%), Rat (%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65744. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KICSTOR complex protein C12orf66; KICSTOR subunit 2; UPF0536 protein
Gene Aliases: C12orf66; KICS2
UniProt ID: (Human) Q96MD2
Entrez Gene ID: (Human) 144577
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