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Highest antigen sequence indentity to the following orthologs: Mouse (76%), Rat (76%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-140242. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adapt78; Calcipressin-1; calcium and oxidant-inducible mRNA; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; MCIP1; modulatory calcineurin-interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; near DSCR proline-rich protein; Regulator of calcineurin 1
Gene Aliases: ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCAN1; RCN1
UniProt ID: (Human) P53805
Entrez Gene ID: (Human) 1827
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