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Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82251. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
ME1 encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); Malic enzyme 1; malic enzyme 1, NADP(+)-dependent, cytosolic; malic enzyme 1, soluble; Malic enzyme, cytoplasmic; NADP-dependent malic enzyme; NADP-ME; pyruvic-malic carboxylase
Gene Aliases: HUMNDME; ME1; MES
UniProt ID: (Human) P48163
Entrez Gene ID: (Human) 4199
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