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Invitrogen
Human ORAI3 (aa 179-244) Control Fragment Recombinant Protein
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Product Details
RP-91115
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
APLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGPGWQA
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (58%), Rat (58%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82518. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
ORAI3 is a protein coding gene that is involved in calcium signaling and regulation of calcium homeostasis. It is a member of the ORAI family of proteins that form calcium release-activated calcium (CRAC) channels in the plasma membrane of cells. These channels are activated by depletion of calcium from the endoplasmic reticulum, leading to an influx of calcium ions into the cytoplasm. ORAI3 has been implicated in a variety of physiological processes, including T-cell activation, muscle contraction, and neurotransmitter release. Dysregulation of ORAI3 expression or function has been associated with various diseases, including immune disorders, cancer, and cardiovascular disease
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein orai-3; Transmembrane protein 142C
Gene Aliases: ORAI3; TMEM142C
UniProt ID: (Human) Q9BRQ5
Entrez Gene ID: (Human) 93129
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