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Highest antigen sequence indentity to the following orthologs: Mouse (89%), Rat (89%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53768. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: APC-stimulated guanine nucleotide exchange factor 1; Asef; DKFZp434G2016; Rho guanine nucleotide exchange factor (GEF) 4; Rho guanine nucleotide exchange factor 4
Gene Aliases: ARHGEF4; ASEF; ASEF1; GEF4; KIAA1112; STM6
UniProt ID: (Human) Q9NR80
Entrez Gene ID: (Human) 50649
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