Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
Highest antigen sequence indentity to the following orthologs: Mouse (97%), Rat (97%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57872. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans. It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles. DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; DnaJ homolog subfamily C member 13; Required for receptor-mediated endocytosis 8; RME-8
Gene Aliases: DNAJC13; KIAA0678; PARK21; RME8
UniProt ID: (Human) O75165
Entrez Gene ID: (Human) 23317
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