Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
General description
• L-Proline is an amino acid that is found as a component of various proteins.
Application
• L-Proline is used as asymmetric catalyst in organic synthesis and asymmetric aldol cyclization
• It is also used along with ninhydrin in chromatography
• It is involved in the Michael addition of dimethyl malonate to alfa-beta-unsaturated aldehydes
• It is used in pharmaceutical and biotechnological applications due to its osmoprotactant property
• It is precursor of hydroxyproline in collage and involved in proper functioning of joint and tendons
Literature References
Northrup A B; MacMillan D W. The first direct and enantioselective cross-aldol reaction of aldehydes.
J Am Chem Soc. 2002, 124 (24), 6798-6799.
Northrup AB; Mangion IK; Hettche F; MacMillan DW. Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates. Angew Chem Int Ed Engl. 2004, 43(16), 2152-4.
List, B. Direct catalytic asymmetric alpha-amination of aldehydes. J Am Chem Soc. 2002, 124, 5656-5657.
Bøgevig, A.; Juhl, K.; Kumaragurubaran, N.; Zhuang, W. and Jørgensen, K.A. Direct Organo-Catalytic Asymmetric α-Amination of Aldehydes—A Simple Approach to Optically Active α-Amino Aldehydes, α-Amino Alcohols, and α-Amino Acids. Angew. Chem. Int. Ed., 2002, 41, 1790-1793
Sferrazza, A.; Triolo, A.; M Migneco, L.; Caminiti, R. Synthesis and Small and Wide-Angle X-Ray Scattering Characterization of L-Proline Based Chiral Ionic Liquids. Curr. Org. Chem. 2015, 19(1), 99-104.
Shimpi, M. R.; Childs, S. L.; Boström, D.; Velaga, S. P. New cocrystals of ezetimibe with l-proline and imidazole. CrystEngComm, 2014, 16(38), 8984-8993.