Bafilomycin A1, 95%
Bafilomycin A1, 95%
Bafilomycin A1, 95%
Thermo Scientific Chemicals

Bafilomycin A1, 95%

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity. | CAS: 88899-55-2 | C35H58O9 | 622.84 g/mol
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Catalog NumberQuantity
3281200010.1 mg
Catalog number 328120001
Price (EUR)
364,65
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440,00
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0.1 mg
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Price (EUR)
364,65
Online Exclusive
440,00
Save 75,35 (17%)
Each
Add to cart
Chemical Identifiers
CAS88899-55-2
IUPAC Name(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-(propan-2-yl)oxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Molecular FormulaC35H58O9
InChI KeyXDHNQDDQEHDUTM-JQWOJBOSSA-N
SMILESCO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C
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SpecificationsSpecification SheetSpecification Sheet
HPLC>=94 %
Appearance (Color)White to off-white
Appearance (Form)Powder or solid
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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
  • It is a macrolide antibiotic, and shows fungicide activity

Application

  • Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
  • It can be immunosuppressive
  • It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
  • It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)
RUO – Research Use Only

General References:

  1. Miao, Y.; Li, G.; Zhang, X.; Xu, H.; Abraham, S. N. A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. Cell. 2015, 161 (6), 1306-1319.
  2. Lee, K. I.; Kim, M. J.; Koh, H.; Lee, J. I.; Namkoong, S.; Oh, W. K.; Park, J.The anti-hypertensive drug reserpine induces neuronal cell death through inhibition of autophagic flux. Biochem. Biophys. Res. Commun. 2015, 462 (4), 402-408.
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Certificates

Lot #Certificate TypeDateCatalog Number(s)
A0469424Certificate of AnalysisFeb 05, 2025328120001
A0462330Certificate of AnalysisApr 30, 2024328120001
A0458126Certificate of AnalysisDec 06, 2023328120001
A0454872Certificate of AnalysisAug 25, 2023328120001
A0451597Certificate of AnalysisMay 02, 2023328120001
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Safety Data Sheets

Safety and Handling

Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Skin Corrosion/Irritation
Category 2
Serious Eye Damage/Eye Irritation
Category 2
Specific target organ toxicity - (single exposure)
Category 3
Label Elements
Signal Word

Warning

Hazard Statements

H315 - Causes skin irritation

H319 - Causes serious eye irritation

H335 - May cause respiratory irritation

Precautionary Statements

P261 - Avoid breathing dust/fume/gas/mist/vapors/spray

P280 - Wear protective gloves/protective clothing/eye protection/face protection

P302 + P352 - IF ON SKIN: Wash with plenty of soap and water

P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

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