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Paclitaxel, 99+%
Catalog number: 328420250
25 mg, Each
Thermo Scientific Chemicals
Paclitaxel, 99+%
Catalog number: 328420250
25 mg, Each
Quantity
Catalog number: 328420250
Price (EUR)
509,40
Online exclusive
566.00
Save 56,60 (10%)
Each
Quantity
-
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Chemical Identifiers
CAS
33069-62-4
IUPAC Name
(1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
Molecular Formula
C47H51NO14
InChI Key
RCINICONZNJXQF-VAZQATRQSA-N
SMILES
CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1
Specifications
Specification SheetAppearance (Color)
White
Appearance (Form)
Powder
Infrared spectrum
Conforms
Melting point
203°C to 223°C
HPLC
>=99.0 %
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Paclitaxel is a naturally ocurring compound originally isolated from the tree T. brevifolia
Paclitaxel binds tubulin and stabilizes microtubule formation, preventing disassembly
Paclitaxel is used as a drug to arrest cells at the mitotic checkpoint and block cell cycle progression, thus inducing death of cancer cells
Applications
Paclitaxel can be used in preclinical laboratory research on diseases such as cancer, heart disease, inflammatory disorders, and hepatic fibrosis
Paclitaxel can be used as a tool in cell biology to study mitotic checkpoint arrest conditions and downstream signaling cascades
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Skin Corrosion/Irritation
Category 2
Serious Eye Damage/Eye Irritation
Category 1
Skin Sensitization
Category 1
Reproductive Toxicity
Category 2
Specific target organ toxicity - (single exposure)
Category 3
Chronic aquatic toxicity
Category 4
Label Elements
Signal Word
Danger
Hazard Statements
H315 - Causes skin irritation
H317 - May cause an allergic skin reaction
H318 - Causes serious eye damage
H335 - May cause respiratory irritation
H361 - Suspected of damaging fertility or the unborn child
H413 - May cause long lasting harmful effects to aquatic life
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor/physician