1-Bromo-4-tert-butylbenzene was used in the synthesis of 4-tert-butyl-phenylboronic acid1, 1-deoxy analogs of CP-47,497 (n = 0 to 7) and 1-deoxy analogs of CP-55,940 (n = 0 to 7). It undergoes lithium-bromide exchange reactions with n-butyllithium and tert-butyllithium at 0°C in various solvents.
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Applications
1-Bromo-4-tert-butylbenzene was used in the synthesis of 4-tert-butyl-phenylboronic acid1, 1-deoxy analogs of CP-47,497 (n = 0 to 7) and 1-deoxy analogs of CP-55,940 (n = 0 to 7). It undergoes lithium-bromide exchange reactions with n-butyllithium and tert-butyllithium at 0°C in various solvents.
Solubility
Insoluble in water.
Notes
Store in cool dry place. Keep away from oxidizing agents.
RUO – Research Use Only
General References:
- Michael Palucki.; Stephen L. Buchwald. Palladium-Catalyzed α-Arylation of Ketones.J. Am. Chem. Soc. 1997, 119 (45),11108-11109 .
- Jens Åhman.; John P. Wolfe.; Malisa V. Troutman.; Michael Palucki.; Stephen L. Buchwald. Asymmetric Arylation of Ketone Enolates.J. Am. Chem. Soc. 1998, 120 (8), 1918-1919 .