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            • Primary Antibodies ›
            • MSK1 Antibodies

            Abnova

            RPS6KA5 Polyclonal Antibody, MaxPab™

            View all (35) MSK1 antibodies
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            Catalog # H00009252-D01P
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            Price (EUR)
            469,00
            100 µg
             
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            Cite RPS6KA5 Polyclonal Antibody, MaxPab™

            • Antibody Testing Data (1)
            Application
            RPS6KA5 Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            RPS6KA5 Antibody (H00009252-D01P) in WB

            Western Blot analysis of RPS6KA5 expression in transfected 293T cell line by RPS6KA5 MaxPab polyclonal antibody. Lane 1: RPS6KA5 transfected lysate(89.90 KDa). Lane 2: Non-transfected lysate. .
            View Product

            RPS6KA5 Antibody in Western Blot (WB)

            Product Details

            H00009252-D01P

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:1,000
            -

            in situ PLA (PLA)

            1:50-1:2,000
            -
            Product Specifications

            Species Reactivity

            Human, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            RPS6KA5 (NP_004746.2, 1 a.a. approximately 802 a.a) full-length human protein.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.5-1 mg/mL

            Purification

            Protein A

            Storage buffer

            PBS, pH 7.4

            Contains

            no preservative

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            Product may be used with Western Blot (Transfected lysate).

            The Isotype of this product is composed of an IgG Mixture.

            Immunogen sequence: MEEEGGSSGG AAGTSADGGD GGEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHK LGIIYRDIKL ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLMKDPKK RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS PAALPQSSEK LFQGYSFVAP SILFKRNAAV IDPLQFHMGV ERPGVTNVAR SAMMKDSPFY QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ AFAVKIISKR MEANTQKEIT ALKLCEGHPN IVKLHEVFHD QLHTFLVMEL LNGGELFERI KKKKHFSETE ASYIMRKLVS AVSHMHDVGV VHRDLKPENL LFTDENDNLE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNQNGYD ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG EAWKNVSQEA KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA VHTCVKATFH AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS HGKTTPTKTL QPSNPADSNN PETLFQFSDS VA

            Target Information

            RPS6KA5 (MSK1) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. RPS6KA5 is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: 90 kDa ribosomal protein S6 kinase 5; kinase MSK1; KS6A5; mitogen and stress-activated protein kinase 1; Nuclear mitogen- and stress-activated protein kinase 1; Ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RSK-like protein kinase; RSKL; S6K-alpha-5

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            Gene Aliases: MSK1; MSPK1; RLPK; RPS6KA5

            View more View less

            UniProt ID: (Human) O75582

            View more View less

            Entrez Gene ID: (Human) 9252, (Rat) 314384

            View more View less

            Function(s)

            magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding histone kinase activity (H3-S10 specific) non-receptor serine/threonine protein kinase protein modifying enzyme

            Process(es)

            negative regulation of cytokine production stimulatory C-type lectin receptor signaling pathway regulation of transcription, DNA-templated protein phosphorylation inflammatory response epidermal growth factor receptor signaling pathway axon guidance histone phosphorylation positive regulation of CREB transcription factor activity positive regulation of histone phosphorylation positive regulation of histone acetylation intracellular signal transduction histone H3-S10 phosphorylation histone H3-S28 phosphorylation histone H2A-S1 phosphorylation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway
            It has to be done as per old AB suggested Products section.
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