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Bleomycin sulfate, Thermo Scientific Chemicals
Catalog number: J60727.MCR
1 mg, Each
Thermo Scientific Chemicals
Bleomycin sulfate, Thermo Scientific Chemicals
Catalog number: J60727.MCR
1 mg, Each
Quantity
Catalog number: J60727.MCR
also known as J60727-M^
Price (EUR)
88,92 Online price
98,80
Each
Quantity
-
Chemical Identifiers
CAS
9041-93-4
IUPAC Name
(3-{[2-(2-{2-[2-(4-{2-[(6-amino-2-{1-[(2-amino-2-carbamoylethyl)amino]-2-carbamoylethyl}-5-methylpyrimidin-4-yl)formamido]-3-{[(2R,3S,4S,5S,6S)-3-{[(2R,3S,4S,5R,6R)-4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3-(1H-imidazol-5-yl)propanamido}-3-hydroxy-2-methylpentanamido)-3-hydroxybutanamido]ethyl}-1,3-thiazol-4-yl)-1,3-thiazol-4-yl]formamido}propyl)dimethylsulfanium hydrogen sulfate
Molecular Formula
C55H85N17O25S4
InChI Key
WUIABRMSWOKTOF-OCBSMOPSSA-N
SMILES
OS([O-])(=O)=O.CC(O)C(NC(=O)C(C)C(O)C(C)NC(=O)C(NC(=O)C1=NC(=NC(N)=C1C)C(CC(N)=O)NCC(N)C(N)=O)C(O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)C1=CN=CN1)C(=O)NCCC1=NC(=CS1)C1=NC(=CS1)C(=O)NCCC[S+](C)C
Specifications
Specification SheetAssay (HPLC)
95.0% min.
Description
Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
- It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
- Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation
Application
- It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
- Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
- Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
- In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Germ Cell Mutagenicity
Category 1B
Carcinogenicity
Category 2
Reproductive Toxicity
Category 2
Label Elements
Signal Word
Danger
Hazard Statements
H340 - May cause genetic defects
H351 - Suspected of causing cancer
H361d - Suspected of damaging the unborn child
Precautionary Statements
P201 - Obtain special instructions before use
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P308 + P313 - IF exposed or concerned: Get medical advice/attention
Additional EU labelling
Restricted to professional users