General Description

• DL-Thioctic acid derives from octanoic acid, and it has been described as an antioxidant coenzyme important for the activity of enzyme complexes including pyruvate dehydrogenase and glycine decarboxylase

Application

• DL-Thioctic acid has been used in studies to increase insulin sensitivity and stimulate glucose uptake into adipose and muscle cells in vitro

• DL-Thioctic acid has an essential role in aerobic metabolism

• It has been used as free radical scavenger compound

• It can also assist in repairing oxidative damage via the increase of endogenous antioxidants, including vitamins C, vitamin E, and glutathione

• It can induce apoptosis through caspase-independent and caspase-dependent pathways, a process mediated by intracellular Ca2+

• DL-Thioctic acid has the ability to impact various cellular biological pathways since it can increase glutathione synthesis and modulate transcription factor activity, mainly nuclear factor kappa B (NF-κB)

• It can decrease the phagocytosis of myelin by macrophages