Paclitaxel, 99+%
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Thermo Scientific Chemicals
Paclitaxel, 99+%
Paclitaxel, also known as Taxol, CAS # 33069-62-4 is a chemotherapeutic drug that acts through stabilizing microtubule assembly and arresting cell cycle progression.
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Catalog number 328420250
Price (EUR)/ Each
509,40
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566.00 
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Quantity:
25 mg
Request bulk or custom format
Price (EUR)/ Each
509,40
Online exclusive
566.00 
Save 56,60 (10%)
Add to cart
Paclitaxel, 99+%
Catalog number328420250
Price (EUR)/ Each
509,40
Online exclusive
566.00 
Save 56,60 (10%)
-
Add to cart
Chemical Identifiers
CAS33069-62-4
IUPAC Name(1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
Molecular FormulaC47H51NO14
InChI KeyRCINICONZNJXQF-VAZQATRQSA-N
SMILESCC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White
Appearance (Form)Powder
Infrared spectrumConforms
Melting point203°C to 223°C
HPLC>=99.0 %
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Paclitaxel is a naturally ocurring compound originally isolated from the tree T. brevifolia
Paclitaxel binds tubulin and stabilizes microtubule formation, preventing disassembly
Paclitaxel is used as a drug to arrest cells at the mitotic checkpoint and block cell cycle progression, thus inducing death of cancer cells
Applications
Paclitaxel can be used in preclinical laboratory research on diseases such as cancer, heart disease, inflammatory disorders, and hepatic fibrosis
Paclitaxel can be used as a tool in cell biology to study mitotic checkpoint arrest conditions and downstream signaling cascades
RUO – Research Use Only

General References:

  1. Zhu, L.; Chen, L. Progress in research on paclitaxel and tumor immunotherapy. Cell Mol Biol Lett. 2019, 24, 40.
  2. Zhang, D.; Yang, R.; Wang, S.; Dong, Z. Paclitaxel: new uses for an old drug. Drug Des Devel Ther. 2014, 8, 279-84.
  3. Weaver, B.A. How Taxol/paclitaxel kills cancer cells. Mol Biol Cell. 2014, 25(18), 2677-81.