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G418 sulfate, for biochemistry
G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic.
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| Catalog Number | Quantity | Packaging |
|---|---|---|
| 329400010 | 1 g | Glass Bottle |
| 329400050 | 5 g | Glass Bottle |
Catalog number 329400010
Price (EUR)
160,65
Online Exclusive
194,00Save 33,35 (17%)
Each
-
Quantity:
1 g
Packaging:
Glass Bottle
Price (EUR)
160,65
Online Exclusive
194,00Save 33,35 (17%)
Each
Chemical Identifiers
CAS108321-42-2
IUPAC Name(2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
Molecular FormulaC20H44N4O18S2
InChI KeyUHEPSJJJMTWUCP-KETIWVBHNA-N
SMILESOS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O
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Specifications
Specification Sheet
Specification SheetAppearance (Form)Powder
Water=<10 %
Potency>=650 µg/mg
Appearance (Color)White to off-white
Infrared spectrumConforms
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis
Applications
• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry
RUO – Research Use Only
Literature references
Arshad, H.; Patel, Z.; Mehrabian, M.; Bourkas, M.; Al-Azzawi, Z.; Schmitt-Ulms, G., & Watts, J. C. 2021. The aminoglycoside G418 hinders de novo prion infection in cultured cells. The Journal of biological chemistry, 297(3), 101073.
Ferguson, M. W.; Gerak, C.; Chow, C.; Rastelli, E. J.; Elmore, K. E.; Stahl, F.; Hosseini-Farahabadi, S.; Baradaran-Heravi, A.; Coltart, D. M., & Roberge, M. 2019. The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418. PloS one, 14(5), e0216423.
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Documents & Downloads
Safety Data Sheets
Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Respiratory Sensitization
Category 1
Skin Sensitization
Category 1
Label Elements
Signal Word
Danger
Hazard Statements
H317 - May cause an allergic skin reaction
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements
P280 - Wear protective gloves/protective clothing
P285 - In case of inadequate ventilation wear respiratory protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P333 + P313 - If skin irritation or rash occurs: Get medical advice/attention
P342 + P311 - If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician