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Minocycline hydrochloride, 97%
Minocycline hydrochloride, 97%, CAS # 13614-98-7, is a broad-spectrum compound with antibacterial and anti-inflammatory activities.
| Catalog Number | Quantity |
|---|---|
| 455330010 | 1 g |
Catalog number 455330010
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Quantity:
1 g
Price (EUR)
110,50
Online Exclusive
130,00Save 19,50 (15%)
Each
Chemical Identifiers
CAS13614-98-7
IUPAC Namehydrogen (2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-1,2,3,4,4a,5,5a,6,12,12a-decahydrotetracene-1,3,12-trione chloride
Molecular FormulaC23H28ClN3O7
InChI KeyKDLQIOPKJDNQIM-WUURTAMISA-N
SMILES[H+].[Cl-].CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(O)=C4C(O)=C3C(=O)[C@]2(O)C(=O)C(=C(N)O)C1=O)N(C)C
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Specifications
Specification Sheet
Specification SheetAppearance (Form)Crystalline powder
Infrared spectrumConforms
HPLC>=96.0 %
Water=<10 %
Appearance (Color)Light yellow to ochre
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Minocycline hydrochloride is the hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities
• This compound exerts its action by binding to the bacterial 30S ribosomal subunit and interfering with the binding of tRNA to the ribosomal complex, resulting in the inhibition of protein translation in bacteria
• Minocycline hydrochloride can inhibit the inflammatory enzyme 5-lipoxygenase (5LOX) and may block T cell-microglia interactions. 5LOX catalyzes the synthesis of inflammatory mediators, including prostaglandins and leukotrienes. Therefore, both molecular activities described may contribute to minocycline's neuroprotective activity.
Applications
• This compound is effective against tetracycline-resistant Staphylococcus cultures • Minocycline hydrochloride inhibits lipopolysaccharide mediated inflammatory cytokine tumor necrosis factor (TNF-α) secretion by macrophages
• It inhibits endothelial cell proliferation and angiogenesis in vitro through the translational suppression of HIF-1α
• This compound exhibits anti-tumor activity in glioma by inhibiting membrane type 1 matrix metalloproteinase
RUO – Research Use Only
Literature References
Liu, D.; Yang, P.S. Minocycline hydrochloride nanoliposomes inhibit the production of TNF-α in LPS-stimulated macrophages. Int J Nanomedicine. 2012, 7, 4769-75. Jung, H.J.; Seo, I.: Jha, B.K.; Suh, S.I.; Suh, M.H.; Baek, W.K. Minocycline inhibits angiogenesis in vitro through the translational suppression of HIF-1α. Arch Biochem Biophys. 2014, 545, 74-82.
Afshari, A.R.; Mollazadeh, H.; Sahebkar, A. Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic. J Oncol. 2020, 8659802. Garrido-Mesa, N.; Zarzuelo, A.; Gálvez, J. Minocycline: far beyond an antibiotic. Br J Pharmacol. 2013, 169 (2), 337-52.
Romero-Miguel, D.; Lamanna-Rama, N.; Casquero-Veiga, M.; Gómez-Rangel, V.; Desco, M.; Soto-Montenegro, M. Minocycline in neurodegenerative and psychiatric diseases: An update. Eur J Neurol. 2021, 28 (3), 1056-1081.
Pfaller, M.; Rhomberg, P.; Huband, M.; Flamm, R. Activities of Omadacycline and Comparator Agents against Staphylococcus aureus Isolates from a Surveillance Program Conducted in North America and Europe. Antimicrob Agents Chemother. 2017, 23, 61 (3), e02411-0216.
Documents & Downloads
Safety Data Sheets
Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Skin Corrosion/Irritation
Category 2
Serious Eye Damage/Eye Irritation
Category 2
Specific target organ toxicity - (single exposure)
Category 3
Label Elements
Signal Word
Warning
Hazard Statements
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P312 - Call a POISON CENTER or doctor if you feel unwell
P332 + P313 - If skin irritation occurs: Get medical advice/attention
P337 + P313 - If eye irritation persists: Get medical advice/attention