Methyl 2-bromobenzoate under Heck reaction with acrylonitrile results in lactonization to give the benzofuran-2-one 3-(cyanomethyl)-2-coumaranone. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals
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Applications
Methyl 2-bromobenzoate under Heck reaction with acrylonitrile results in lactonization to give the benzofuran-2-one 3-(cyanomethyl)-2-coumaranone. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals
Solubility
Insoluble in water.
Notes
Store in a cool place. Keep away from oxidizing agents.
RUO – Research Use Only
Stephan Thorand.; Norbert Krause. Improved Procedures for the Palladium-Catalyzed Coupling of Terminal Alkynes with Aryl Bromides (Sonogashira Coupling). J. Org. Chem. 1998, 63 (23),8551-8553.
Carsten Bolm.; Jens P. Hildebrand. Palladium-catalyzed carbonnitrogen bond formation: A novel, catalytic approach towards N-arylated sulfoximines. Tetrahedron Lett.. 1998, 39 (32),5731-5734.
Heck reaction with acrylonitrile results in lactonization to give the benzofuran-2-one 3-(cyanomethyl)-2-coumaranone: J. Heterocycl. Chem., 32, 1587 (1995):