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Ethyl hydrogen malonate, 96%, Thermo Scientific Chemicals
Catalog number: A12627.09
10 g, Each
Thermo Scientific Chemicals
Ethyl hydrogen malonate, 96%, Thermo Scientific Chemicals
Catalog number: A12627.09
10 g, Each
Quantity
Catalog number: A12627.09
also known as A12627-09
Price (EUR)
36,90 Online price
41,00
Each
Quantity
-
Chemical Identifiers
CAS
1071-46-1
IUPAC Name
3-ethoxy-3-oxopropanoic acid
Molecular Formula
C5H8O4
InChI Key
HGINADPHJQTSKN-UHFFFAOYSA-N
SMILES
CCOC(=O)CC(O)=O
Specifications
Specification SheetAppearance (Color)
Clear colorless to pale yellow
Assay (Aqueous acid-base Titration)
≥95.0 to ≤105.0%
Refractive Index
1.4245-1.4320 @ 20?C
Water Content (Karl Fischer Titration)
≤2%
Form
Liquid
Description
Ethyl hydrogen malonate is used as a reactant for the preparation of tetramic acids through Dieckmann ring closure and organocatalytic decarboxylative Doebner-Knoevenagel reactions. It is involved in the acylation reactions and Knoevenagel condensation with aldehydes. It is also used in the preparation of gamma-lactones from olefins by intermolecular carbolactonization in presence of Mn(III) acetate as a catalyst.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Ethyl hydrogen malonate is used as a reactant for the preparation of tetramic acids through Dieckmann ring closure and organocatalytic decarboxylative Doebner-Knoevenagel reactions. It is involved in the acylation reactions and Knoevenagel condensation with aldehydes. It is also used in the preparation of gamma-lactones from olefins by intermolecular carbolactonization in presence of Mn(III) acetate as a catalyst.
Solubility
Miscible with water, chloroform and other solvents.
Notes
Incompatible with strong oxidizing agents.
Ethyl hydrogen malonate is used as a reactant for the preparation of tetramic acids through Dieckmann ring closure and organocatalytic decarboxylative Doebner-Knoevenagel reactions. It is involved in the acylation reactions and Knoevenagel condensation with aldehydes. It is also used in the preparation of gamma-lactones from olefins by intermolecular carbolactonization in presence of Mn(III) acetate as a catalyst.
Solubility
Miscible with water, chloroform and other solvents.
Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Skin Corrosion/Irritation
Category 2
Serious Eye Damage/Eye Irritation
Category 2
Specific target organ toxicity - (single exposure)
Category 3
Label Elements
Signal Word
Warning
Hazard Statements
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary Statements
P261 - Avoid breathing dust/fume/gas/mist/vapors/spray
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P332 + P313 - If skin irritation occurs: Get medical advice/attention
P337 + P313 - If eye irritation persists: Get medical advice/attention