Thermo Scientific Chemicals

Indomethacin, 98%, Thermo Scientific Chemicals

Catalog number: A19910.06
5 g, Each
Thermo Scientific Chemicals

Indomethacin, 98%, Thermo Scientific Chemicals

Catalog number: A19910.06
5 g, Each
Quantity
Catalog number: A19910.06
also known as A19910-06
Price (EUR)
Quantity
-

Chemical Identifiers

CAS
53-86-1
IUPAC Name
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
Molecular Formula
C19H16ClNO4
InChI Key
CGIGDMFJXJATDK-UHFFFAOYSA-N
SMILES
COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1
Assay (Aqueous acid-base Titration)
≥97.5 to ≤102.5%
Melting Point (clear melt)
156.0-163.0?C
Form
Powder
Appearance (Color)
White to pale cream
Assay (HPLC)
≥97.5%

Description

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Notes
Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only

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    Safety and Handling


    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Acute oral toxicity
    Category 2
    Skin Sensitization
    Category 1
    Reproductive Toxicity
    Category 1B
    Label Elements
    Signal Word

    Danger

    Hazard Statements

    H300 - Fatal if swallowed

    H317 - May cause an allergic skin reaction

    H360FD - May damage fertility. May damage the unborn child

    Precautionary Statements

    P201 - Obtain special instructions before use

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting

    P302 + P352 - IF ON SKIN: Wash with plenty of soap and water

    P308 + P313 - IF exposed or concerned: Get medical advice/attention

    P405 - Store locked up

    Additional EU labelling

    Restricted to professional users