Thermo Scientific Chemicals

Benzyloxyacetyl chloride, 95%, Thermo Scientific Chemicals

Catalog number: L14337.06
5 g, Each
Thermo Scientific Chemicals

Benzyloxyacetyl chloride, 95%, Thermo Scientific Chemicals

Catalog number: L14337.06
5 g, Each
Quantity
Catalog number: L14337.06
also known as L14337-06
Price (EUR)
Quantity
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Chemical Identifiers

CAS
19810-31-2
IUPAC Name
2-(benzyloxy)acetyl chloride
Molecular Formula
C9H9ClO2
InChI Key
QISAUDWTBBNJIR-UHFFFAOYSA-N
SMILES
ClC(=O)COCC1=CC=CC=C1
Form
liquid
Refractive Index
1.5195 - 1.5265
Appearance (Color)
Clear, colourless to pale yellow
Assay (Methyl Ester GC)
>94.0%

Description

Benzyloxyacetyl chloride is a reagent used to construct substituted 2-azetidinones for further elaboration into annulated β-lactams. It is a commonly employed reagent for asymmetric synthesis of β-lactams. It is also used in preparation of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections, non-racemic helicene and β-lactams.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Benzyloxyacetyl chloride is a reagent used to construct substituted 2-azetidinones for further elaboration into annulated β-lactams. It is a commonly employed reagent for asymmetric synthesis of β-lactams. It is also used in preparation of (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections, non-racemic helicene and β-lactams.

Solubility
Reacts with water.

Notes
It is sensitive to moisture. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature is 2 - 8°C. Store under inert gas.
RUO – Research Use Only

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    Safety and Handling


    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Skin Corrosion/Irritation
    Category 1
    Serious Eye Damage/Eye Irritation
    Category 1
    Label Elements
    Signal Word

    Danger

    Hazard Statements

    H314 - Causes severe skin burns and eye damage

    EU Specific Hazard Statements

    EUH014 - Reacts violently with water

    EUH029 - Contact with water liberates toxic gas

    Precautionary Statements

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P301 + P330 + P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting

    P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower

    P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

    P310 - Immediately call a POISON CENTER or doctor/physician