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SCF (C-Kit Ligand) Recombinant Human Protein
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Gibco™

SCF (C-Kit Ligand) Recombinant Human Protein

Recombinant Human Stem Cell Factor (SCF) is a bioactive protein intended for use in cell culture applications. SCF is aMás información
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Número de catálogoCantidad
CTP21131 mg
Número de catálogo CTP2113
Precio (EUR)
7.330,00
1 mg
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Cantidad:
1 mg
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Precio (EUR)
7.330,00
1 mg
Añadir al carro de la compra
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Recombinant Human Stem Cell Factor (SCF) is a bioactive protein intended for use in cell culture applications. SCF is a pleiotropic factor that acts in utero in germ cell and neural cell development and hematopoiesis. These activities are all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. The lyophilized, E. coli-expressed SCF Recombinant Human is verified for activity through dose-dependent proliferation of human MO-7e cells.

Highly Pure—minimizes interference from other proteins or contaminants
Active—get more results with less protein

High Purity
To help verify that GIBCO™ Recombinant growth factors are of the highest quality, each protein is analyzed for purity, along with structural homogeneity, to help ensure a biologically active protein. The purity of each GIBCO™ recombinant growth factor is verified by SDS-PAGE to be over 95% and to have endotoxin levels below 0.1 ng/μg.

High Biological Activity
All GIBCO™ Recombinant growth factors are verified for activity. Each lot has its own ED50 determined using an activity assay based on a specific function of the growth factor. The activity of our SCF Recombinant Human growth factor is determined by the dose-dependent proliferation of human MO-7e cells to have an ED50 range of 2–10 ng/mL (specific activity: 5 × 105–1 × 105 units/mg). Optimal concentration for individual applications should be determined by a dose response assay.

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For Research Use Only. Not for use in diagnostic procedures.
Especificaciones
Para utilizar con (aplicación)Cell Culture
Peso molecular18.5 kDa
Método de purificaciónSequential Chromatography
Cantidad1 mg
FuenteHuman
Alias de genSCF (c-kit Ligand)
Longitud de la proteína164 aa
EspecieHuman
RecombinanteRecombinant
ClasificaciónCarrier-Free
Actividad2 ng/ml
BioensayoProliferation of MO7e cells
Nivel de endotoxinas<0.1 ng/μg
Condiciones de envíoWet Ice
Sistema de expresiónE. coli
Familia de proteínasGrowth Factors & Receptors
Forma de proteínaFull Length, Recombinant, Ligand
FormularioLyophilized
Subtipo de proteínaOther Proteins
Categoría de investigaciónClinical Research, Stem Cell Research, Differentiation, Oncology
Línea de productosGibco™
Grado de pureza o calidad95 %
Unit Size1 mg
Contenido y almacenamiento
2°C to 8°C
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Documentos y descargas

Certificados

N.º de loteCertificate TypeDateCatalog Number(s)
2402733Certificate of Analysis29 dic 2021CTP2113
2360057Certificate of Analysis29 jun 2021CTP2113
2109031Certificate of Analysis18 jun 2019CTP2113
1726061Certificate of Analysis13 jun 2018CTP2113
1671589Certificate of Analysis16 abr 2017CTP2113
Se muestran 5 resultados, busque arriba un certificado específico

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Product Information

Citations & References (10)

Citations & References
Abstract
PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids.
Authors:Foulks JM, Marathe GK, Michetti N, Stafforini DM, Zimmerman GA, McIntyre TM, Weyrich AS
Journal:Blood
PubMed ID:19395675
'Platelet activating factor (PAF) and PAF-like lipids induce inflammatory responses in target cells. These lipid mediators are inactivated by PAF-acetylhydrolase (PAF-AH). The PAF signaling system affects the growth of hematopoietic CD34(+) cells, but roles for PAF-AH in this process are unknown. Here, we investigated PAF-AH function during megakaryopoiesis and found ... More
Correlations of cell surface antigens with individual differences in radiosensitivity in human hematopoietic stem/progenitor cells.
Authors:Takahashi K, Monzen S, Hayashi N, Kashiwakura I
Journal:Radiat Res
PubMed ID:20095850
'To characterize the differences in the radiosensitivity of individual populations of human hematopoietic stem/progenitor cells (HSPCs), we examined the relationship among cell surface antigens, clonogenic potential and radiation survival. The expressions of CD34, CD38, CD45RA, CD110 and Tie-2, early differentiation pathway-related antigens in hematopoiesis, were analyzed on the surface of ... More
Radiosensitivity of human haematopoietic stem/progenitor cells.
Authors:Kato K, Omori A, Kashiwakura I
Journal:J Radiol Prot
PubMed ID:23295782
'The haematopoietic system is regenerative tissue with a high proliferative potential; therefore, haematopoietic stem cells (HSCs) are sensitive to extracellular oxidative stress caused by radiation and chemotherapeutic agents. An understanding of this issue can help predict haematopoietic recovery from radiation exposure as well as the extent of radiation damage to ... More
Immobilization, stabilization, and activation of human stem cell factor (SCF) on fragmin/protamine microparticle (F/P MP)-coated plates.
Authors:Kishimoto S, Oonuma F, Nakamura S, Hattori H, Nakamura S, Mori Y, Tanaka Y, Harada Y, Tagawa M, Ishihara M
Journal:J Biomed Mater Res B Appl Biomater
PubMed ID:19637375
'Fragmin (low-molecular-weight heparin)/protamine microparticles (F/P MPs) immobilize to culture plates, thereby retaining the binding of heparin-binding cytokines such as human stem cell factor (SCF). The purpose of this study was to evaluate the ability of F/P MP-coating to immobilize, stabilize, and enhance SCF-activity. Cell assays showed that SCF and preimmobilized ... More
The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation.
Authors:Yasinska IM, Gibbs BF, Lall GS, Sumbayev VV
Journal:
PubMed ID:23872956
Mammalian myeloid cells are crucial effectors of host innate immune defense. Normal and pathological responses of these cells require adaptation to signaling stress through the hypoxia-inducible factor 1 (HIF-1) transcription complex. Adapted cells activate the mammalian target of rapamycin (mTOR), via S2448 phosphorylation, which induces de novo translation of vital ... More
10 total citations

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