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Thermo Scientific Chemicals

Doxorubicin hydrochloride, Thermo Scientific Chemicals

Número de catálogo: J64000.MF
50 mg, Each
Doxorubicin hydrochloride, Thermo Scientific Chemicals
Doxorubicin hydrochloride, Thermo Scientific Chemicals
Doxorubicin hydrochloride, Thermo Scientific Chemicals
Certificados
Thermo Scientific Chemicals

Doxorubicin hydrochloride, Thermo Scientific Chemicals

Número de catálogo: J64000.MF
50 mg, Each
Cantidad
Certificados
Informational:Con fines informativos:Este producto químico puede requerir que obtengamos información adicional para nuestros registros de cumplimiento normativo y químico. Si es necesario, nos pondremos en contacto con usted para obtener esta información una vez que haya realizado su pedido.
Número de catálogo: J64000.MF
también denominado J64000-MF
Precio (EUR)
484,00
Each
Cantidad
-
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Identificadores químicos

CAS
25316-40-9
IUPAC Name
hydrogen (8S,10S)-10-[(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione chloride
Molecular Formula
C27H30ClNO11
InChI Key
MWWSFMDVAYGXBV-FGBJBKNOSA-N
SMILES
[H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O

Especificaciones

Hoja de especificacionesHoja de especificaciones
Assay from Suppliers CofA
≥97.0%
Form
Crystalline powder or granular
Appearance (Color)
Red to orange

Descripción

Antitumor antibiotic agent that inhibits DNA topoisomerase II.Doxorubicin hydrochloride is used as an antineoplastic, antibiotic agent that inhibits DNA topoisomerase. It also inhibits nucleic acid synthesis and induces apoptosis. It posses fluorescent property, which enable it for the measurement of drug efflux pump activities and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Doxorubicin hydrochloride, isolated from the bacterium Streptomyces peucetius, is an anthracycline antibiotic with antineoplastic activity and is related to daunorubicin
  • It can intercalate between base pairs in the DNA helix preventing DNA replication
  • It also inhibits the nucleic acid synthesis and can induce apoptosis
  • It can inhibit DNA topoisomerase II, resulting in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication, and prevents nucleotide strand ligation after double-strand breakage
  • Doxorubicin hydrochloride forms oxygen free radicals that result in cytotoxicity and lead to the lipid peroxidation of cell membrane lipids

Application

  • This compound displays a fluorescent property allowing the measurement of drug efflux pump activity and examining the role of subcellular organelles (Golgi complex and lysosome) in the sequestration of drugs
  • It has been used in cell viability assays
  • It is used as a drug in polymeric PLGA-based microparticulate drug delivery and to develop in vitro doxorubicin-resistant HepG2 cells (HepG2-DR) and K562 cells (K562-DR)
  • It is a substrate of the MRP1 transporter
RUO – Research Use Only

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    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Acute oral toxicity
    Category 4
    Skin Corrosion/Irritation
    Category 2
    Serious Eye Damage/Eye Irritation
    Category 1
    Germ Cell Mutagenicity
    Category 1A
    Reproductive Toxicity
    Category 2
    Specific target organ toxicity - (single exposure)
    Category 3
    Label Elements
    Signal Word

    Danger

    Hazard Statements

    H302 - Harmful if swallowed

    H315 - Causes skin irritation

    H318 - Causes serious eye damage

    H335 - May cause respiratory irritation

    H340 - May cause genetic defects

    H361fd - Suspected of damaging fertility. Suspected of damaging the unborn child

    Precautionary Statements

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting

    P302 + P352 - IF ON SKIN: Wash with plenty of soap and water

    P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing

    P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

    P310 - Immediately call a POISON CENTER or doctor/physician

    P332 + P313 - If skin irritation occurs: Get medical advice/attention

    Additional EU labelling

    Restricted to professional users