Thermo Scientific Chemicals

N,N-Dimetilfosforamidodicloridato, 97 %, Thermo Scientific Chemicals

Número de catálogo: L07231.06
5 g, Each
Thermo Scientific Chemicals

N,N-Dimetilfosforamidodicloridato, 97 %, Thermo Scientific Chemicals

Número de catálogo: L07231.06
5 g, Each
Cantidad
Número de catálogo: L07231.06
Precio (EUR)

Identificadores químicos

CAS
677-43-0
IUPAC Name
(dimethylamino)phosphonoyl dichloride
Molecular Formula
C2H6Cl2NOP
InChI Key
YNHXBEVSSILHPI-UHFFFAOYSA-N
SMILES
CN(C)P(Cl)(Cl)=O
Phosphorus-31 NMR
>96.0%

Descripción

N,N-Dimethylphosphoramidodichloridate is used in the synthesis of phosphoramidates as well as (RS)-ethyl N,N-dimethylphosphoramidocyanidate (Nerve agent GA) which is used as a chemical weapon. It forms active intermediates, which react with alcohols in situ to give esters. It is also used to convert primary alcohols to alkyl chlorides. Furthe, it serves as an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. In addition to this, it reacts with 1,2 diols to prepare cyclic phosphoric amides followed by alkenes after reduction.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
El N,N-dimetilfosforamidodicloridato se utiliza en la síntesis de fosforamidatos, así como el N,N-dimetilfosforamidocianidato de (RS)-etilo (agente nervioso GA) que se utiliza como arma química. Forma intermedios activos, que reaccionan con los alcoholes in situ para dar lugar a ésteres. También se utiliza para convertir alcoholes primarios en cloruros de alquilo. Asimismo, sirve como una importante materia prima y un intermedio utilizado en la síntesis orgánica, los productos farmacéuticos, los agroquímicos y los colorantes. Además de esto, reacciona con 1,2 dioles para preparar amidas fosfóricas cíclicas seguidas de alquenos después de la reducción.

Solubilidad
Miscible con dimetoxietano.

Notas
Sensible a la humedad y al aire. Higroscópico. Almacenar en lugar fresco. Mantenga el recipiente bien cerrado en un lugar seco y bien ventilado. Incompatible con agentes oxidantes fuertes.
RUO – Research Use Only

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    Seguridad y manipulación


    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Skin Corrosion/Irritation
    Category 1
    Serious Eye Damage/Eye Irritation
    Category 1
    Label Elements
    Signal Word

    Danger

    Hazard Statements

    H314 - Causes severe skin burns and eye damage

    Precautionary Statements

    P280 - Wear protective gloves/protective clothing/eye protection/face protection

    P301 + P330 + P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting

    P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower

    P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

    P310 - Immediately call a POISON CENTER or doctor/physician