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Mitomycin C, contains 2 mg Mitomycin C and 48 mg NaCl
Mitomycin C, CAS # 50-07-7, is a methylazirinopyrroloindoledione complex isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. It is a versatile and potent compound with antibiotic activity and may have potential therapeutic value in the treatment of cancer. | CAS: 50-07-7 | C15H18N4O5 | 334.32 g/mol
| Catalog Number | Quantity |
|---|---|
| 226940020 | 2 mg |
Catalog number 226940020
Price (EUR)
113,05
Online Exclusive
136,00Save 22,95 (17%)
Each
Quantity:
2 mg
Price (EUR)
113,05
Online Exclusive
136,00Save 22,95 (17%)
Each
Chemical Identifiers
CAS50-07-7
IUPAC Name[(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0²,⁷.0⁴,⁶]trideca-1(9),11-dien-8-yl]methyl carbamate
Molecular FormulaC15H18N4O5
InChI KeyNWIBSHFKIJFRCO-WUDYKRTCSA-N
SMILESCO[C@]12[C@H]3N[C@H]3CN1C1=C([C@H]2COC(N)=O)C(=O)C(N)=C(C)C1=O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Grey to blue
Appearance (Form)Powder
HPLC>=99 % with regard to the non-formulated material
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
- Mitomycin C is a water soluble, blue-violet crystalline powder, unstable in light and acidic conditions, but may be stably stored at 2-8°c
- Bio-reduced mitomycin C generates oxygen radicals, alkylates DNA, and produces inter-strand DNA cross-links, thereby inhibiting DNA synthesis
Applications
- Mitomycin C is preferentially toxic to hypoxic cells that are resistant to cancer therapy, and is therefore used to study its potential therapeutic effect on advanced stages of cancer
- At high concentrations, mitomycin C inhibits RNA and protein synthesis and demonstrates strong antibiotic properties towards both Gram-positive and Gram-negative bacteria
RUO – Research Use Only
Literature References: Verweij, J.; Pinedo, H. M. Mitomycin C: mechanism of action, usefulness and limitations. Anticancer Drugs. 1990, 1(1), 5-13.Tomasz, M.; Mitomycin, C. Small, fast and deadly (but very selective). Chem Biol. 1995, 2(9), 575-9. Teus, M. A.; de Benito-Llopis, L.; Alió, J.L. Mitomycin C in corneal refractive surgery. Surv Ophthalmol. 2009 Jul-Aug;54(4):487-502.
Documents & Downloads
Safety Data Sheets
Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 4
Carcinogenicity
Category 2
Label Elements
Signal Word
Warning
Hazard Statements
H302 - Harmful if swallowed
H351 - Suspected of causing cancer
Precautionary Statements
P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P201 - Obtain special instructions before use
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P308 + P313 - IF exposed or concerned: Get medical advice/attention