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Colistin sulfate salt
Colistin Sulfate salt (2:5), CAS # 1264-72-8, (synonym: Polymyxin E Complex), is a complex mixture of antibiotics, with Colistin A and B being the primary components. It has anti-bacterial activity against Gram-positive and Gram-negative bacteria and may also be used as a neuromuscular blocker.
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| Catalog Number | Quantity |
|---|---|
| 455392500 | 250 mg |
| 455390010 | 1 g |
Catalog number 455392500
Price (EUR)
51,68
Precio exclusivo en nuestra web
60,80Save 9,12 (15%)
Each
-
Quantity:
250 mg
Price (EUR)
51,68
Precio exclusivo en nuestra web
60,80Save 9,12 (15%)
Each
Chemical Identifiers
CAS1264-72-8
IUPAC NameN-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide; sulfuric acid
Molecular FormulaC53H102N16O17S
InChI KeyZJIWRHLZXQPFAD-LRYSGCCDSA-N
SMILESOS(O)(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O
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Specifications
Specification Sheet
Specification SheetAdditional infoMay contain up to 15 % water
Additional infoMay contain up to 15 % water
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• Colistin Sulfate salt is a stable, cationic, water-soluble, white powder composed of over 30 components
• Originally isolated from B. polymyxa, it inhibits the growth of the Gram-negative (e.g. E. coli, P. aeruginosa, P. fluorescens, and S. enterica), and Gram-positive bacteria (e.g. L. lactis, P. polymyxa, P. acidilactici, and S. aureus) by permeabilizing the bacterial cell membrane
Applications
• Colistin Sulfate has potent anti-endotoxin activity rendered through its ability to bind lippopolysaccharides that make up bacterial endotoxins
• This compound is often used in the management of multi-drug resistant Gram-negative infections
RUO – Research Use Only
Literature References:
Falagas, M. E.; Kasiakou, S. K.; Saravolatz, L. D. Colistin: The Revival of Polymyxins for the Management of Multidrug-Resistant Gram-Negative Bacterial Infections Clinical Infectious Diseases. 2005, 40 (9), 1333–1341.
Suzuki, T.; Inouye, H.; Fujikawa, K.; et al. Studies on the chemical structure of colistin. I. Fractionation, molecular weight determination, amino acid and fatty acid composition. J. Biochem. 1963, 54(1), 25-33.
Naghmouchi, K.; Hammami, R.; Fliss, I.; et al. Colistin A and colistin B among inhibitory substances of Paenibacillus polymyxa JB05-01-1. Arch. Microbiol. 2012, 194(5), 363-370.
Mitsugui, C.S.; Tognim, M.C.B.; Cardoso, C.L.; et al. In vitro activity of polymyxins in combination with β-lactams against clinical strains of Pseudomonas aeruginosa. Int. J. Antimicrob. 2011, 38(5), 447-450.
Documents & Downloads
Safety Data Sheets
Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 3
Label Elements
Signal Word
Danger
Hazard Statements
H301 - Toxic if swallowed
Precautionary Statements
P264 - Wash face, hands and any exposed skin thoroughly after handling
P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician