Thermo Scientific Chemicals

Diphenyl phosphorochloridate, 97%, Thermo Scientific Chemicals

Catalog number: A13546.18
50 g, Each
Thermo Scientific Chemicals

Diphenyl phosphorochloridate, 97%, Thermo Scientific Chemicals

Catalog number: A13546.18
50 g, Each
Quantity
Catalog number: A13546.18
also known as A13546-18
Price (EUR)
Quantity
-

Chemical Identifiers

CAS
2524-64-3
IUPAC Name
diphenyl phosphorochloridate
Molecular Formula
C12H10ClO3P
InChI Key
BHIIGRBMZRSDRI-UHFFFAOYSA-N
SMILES
ClP(=O)(OC1=CC=CC=C1)OC1=CC=CC=C1
Refractive Index
1.5470-1.5520 @ 20?C
Appearance (Color)
Clear colorless
Form
Liquid
Assay (GC)
≥96.0%

Description

Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5',5'-triphosphate, guanosine-cytidine-5',5'-triphosphate, guanosine-uridine-5',5'-triphosphate, diguanosine-5',5'-diphosphate and diguanosine-5',5'-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5′,5′-triphosphate, guanosine-cytidine-5′,5′-triphosphate, guanosine-uridine-5′,5′-triphosphate, diguanosine-5′,5′-diphosphate and diguanosine-5′,5′-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

Solubility
Immiscible with water.

Notes
Moisture sensitive. Incompatible with strong bases and strong oxidizing agents.
RUO – Research Use Only

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    Safety and Handling


    Classification of the substance or mixture
    CLP classification - Regulation(EC) No 1272/2008
    Skin Corrosion/Irritation
    Category 1
    Serious Eye Damage/Eye Irritation
    Category 1
    Label Elements
    Signal Word

    Danger

    Hazard Statements

    H314 - Causes severe skin burns and eye damage

    EU Specific Hazard Statements

    EUH029 - Contact with water liberates toxic gas

    Precautionary Statements

    P402 + P404 - Store in a dry place. Store in a closed container

    P280 - Wear eye protection/ face protection

    P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting

    P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

    P310 - Immediately call a POISON CENTER or doctor/physician