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p-Toluenesulfonylmethyl isocyanide, 97%, Thermo Scientific Chemicals
Catalog number: A14312.06
5 g, Each
Thermo Scientific Chemicals
p-Toluenesulfonylmethyl isocyanide, 97%, Thermo Scientific Chemicals
Catalog number: A14312.06
5 g, Each
Quantity
Catalog number: A14312.06
also known as A14312-06
Price (EUR)
30,51 Online price
33,90
Each
Quantity
-
Chemical Identifiers
CAS
36635-61-7
IUPAC Name
1-isocyanomethanesulfonyl-4-methylbenzene
Molecular Formula
C9H9NO2S
InChI Key
CFOAUYCPAUGDFF-UHFFFAOYSA-N
SMILES
CC1=CC=C(C=C1)S(=O)(=O)C[N+]#[C-]
Specifications
Specification SheetAppearance (Color)
White to cream or pale yellow to pale brown
Clarity
(2.5% soln. in Acetone): Clear to almost clear
Identification (FTIR)
Conforms
Assay (HPLC)
≥96.0%
Form
Crystalline powder or powder
Description
p-Toluenesulfonylmethyl isocyanide is a synthetic reagent used in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton, pyrroles, oxazoles and in imidazoles. It serves as an isonitrile component in a diastereoselective Passerini reaction. Furthermore, it is used in the Van Leusen reaction to convert aldehydes to nitriles.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
p-Toluenesulfonylmethyl isocyanide is a synthetic reagent used in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton, pyrroles, oxazoles and in imidazoles. It serves as an isonitrile component in a diastereoselective Passerini reaction. Furthermore, it is used in the Van Leusen reaction to convert aldehydes to nitriles.
Solubility
Soluble in chloroform and methanol. Insoluble in water.
Notes
Moisture, air and light sensitive. Store in cool place. Incompatible with strong bases and strong oxidizing agents.
p-Toluenesulfonylmethyl isocyanide is a synthetic reagent used in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton, pyrroles, oxazoles and in imidazoles. It serves as an isonitrile component in a diastereoselective Passerini reaction. Furthermore, it is used in the Van Leusen reaction to convert aldehydes to nitriles.
Solubility
Soluble in chloroform and methanol. Insoluble in water.
Notes
Moisture, air and light sensitive. Store in cool place. Incompatible with strong bases and strong oxidizing agents.
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 3
Acute Inhalation Toxicity - Dusts and Mists
Category 3
Respiratory Sensitization
Category 1
Reproductive Toxicity
Category 2
Label Elements
Signal Word
Danger
Hazard Statements
H301 + H331 - Toxic if swallowed or if inhaled
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
H361 - Suspected of damaging fertility or the unborn child
Precautionary Statements
P264 - Wash face, hands and any exposed skin thoroughly after handling
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P284 - Wear respiratory protection
P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P311 - Call a POISON CENTER or doctor/physician