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Product Details
H00008672-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1B4
Immunogen
EIF4G3 (AAH30578, 1 a.a. approximately 515 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MNSQPQTRSP FAAGPRPPHH QFFQRPQIQP PRATIPNSSP SIRPGAQTPT AVYQANQHIM MVNHLPMPYP VPQGPQYCIP QYRHSGPPYV GPPQQYPVQP PGPGPFYPGP GPGDFPNAYG TPFYPSQPVY QSAPIMVPTQ QQPPPAKREK KTIRIRDPNQ GGKDITEEII SGGGSRNPTP PIGRPTSTPT PPQQLPSQVP EHSPVVYGTV ESAHLAASTP VTAASDQKQE EKPKPDPVLK SPSPVLRLVL SGEKKEQEGQ TSETTAIVSI AELPLPPSPT TVSSVARSTI AAPTSSALSS QPIFTTAIDD RCELSSPRED TIPIPSLTSC TETSDPLPTN ENDGDICKKP CSVAPNDIPL VSSTNLINEI NGVSEKLSAT ESIVEIVKQE VLPLTLELEI LENPPEEMKL ECIPAPITPS TVPSFPPTPP TPPASPPHTP VIVPAAATTV SSPSAAITVQ RVLEEDESIR TCLSEDAKEI QNKIEVEADG QTEEILDSQN LNSRRSPVPE TSNEC
Target Information
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-4-gamma 3; eIF-4-gamma II; eIF4GII; Eukaryotic translation initiation factor 4 gamma 3; RP11-190H11.1
Gene Aliases: eIF-4G 3; eIF4G 3; EIF4G3; eIF4GII
UniProt ID: (Human) O43432
Entrez Gene ID: (Human) 8672
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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