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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%, Thermo Scientific Chemicals
Catalog number: H26473.03
1 g, Each
Thermo Scientific Chemicals
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%, Thermo Scientific Chemicals
Catalog number: H26473.03
1 g, Each
Quantity
Catalog number: H26473.03
also known as H26473-03
Price (EUR)
643,50 Online price
715,00
Each
Quantity
-
Chemical Identifiers
CAS
30827-99-7
IUPAC Name
hydrogen 4-(2-aminoethyl)benzene-1-sulfonyl fluoride chloride
Molecular Formula
C8H11ClFNO2S
InChI Key
WRDABNWSWOHGMS-UHFFFAOYSA-N
SMILES
[H+].[Cl-].NCCC1=CC=C(C=C1)S(F)(=O)=O
Specifications
Specification SheetForm
Powder
Melting Point
ca. 180-190?C dec.
Appearance (Color)
White
Proton NMR
To conform to structure
Assay (HPLC)
≥96.0%
Description
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
Solubility
Soluble in water 50 mg/mL or 100% ethanol.
Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
Solubility
Soluble in water 50 mg/mL or 100% ethanol.
Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Skin Corrosion/Irritation
Category 1
Serious Eye Damage/Eye Irritation
Category 1
Label Elements
Signal Word
Danger
Hazard Statements
H314 - Causes severe skin burns and eye damage
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P301 + P330 + P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting
P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor/physician