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Milrinone, 98+%, Thermo Scientific Chemicals
Catalog number: J62659.MF
50 mg, Each
Thermo Scientific Chemicals
Milrinone, 98+%, Thermo Scientific Chemicals
Catalog number: J62659.MF
50 mg, Each
Quantity
Catalog number: J62659.MF
also known as J62659-MF
Price (EUR)
453,01 Online price
509,00
Each
Quantity
-
Chemical Identifiers
CAS
78415-72-2
IUPAC Name
2-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile
Molecular Formula
C12H9N3O
InChI Key
PZRHRDRVRGEVNW-UHFFFAOYSA-N
SMILES
CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1
Specifications
Specification SheetAppearance (Color)
Pale cream to cream
Residue on ignition
≤0.5%
Form
Powder or crystals or crystalline powder
Loss on Drying
≤1.0%
Assay from Supplier's CofA
≥98.0%
Description
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
Solubility
Soluble in DMSO. Insoluble in water.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.
Solubility
Soluble in DMSO. Insoluble in water.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only
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Safety and Handling
Classification of the substance or mixture
CLP classification - Regulation(EC) No 1272/2008
Acute oral toxicity
Category 3
Acute dermal toxicity
Category 3
Acute Inhalation Toxicity - Dusts and Mists
Category 3
Label Elements
Signal Word
Danger
Hazard Statements
H301 + H311 + H331 - Toxic if swallowed, in contact with skin or if inhaled
Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P302 + P350 - IF ON SKIN: Gently wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P310 - Immediately call a POISON CENTER or doctor/physician
P312 - Call a POISON CENTER or doctor if you feel unwell