TSAT (tris-(succinimidyl)aminotriacetate)

Thermo Scientific Pierce TSAT is tris-(succinimidyl) aminotriacetate, a novel trifunctional crosslinker that contains three short spacers arms linked to a central nitrogen atom, each ending in an amine-reactive NHS-ester group.

Features of TSAT:

• Reactive groups: NHS ester (three ends)
• Reactive towards: amino groups (primary amines)
• NHS ester couples to amines at pH 7-9 form stable amide bonds
• Trifunctional amine-reactive crosslinking agent
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)

Applications:
• Preparation of multicomponent aggregates
• Polyerization of protein interactions for nearest-neighbor studies
• Core molecule for the construction of dendritic polymers

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

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TSAT (tris-(succinimidyl)aminotriacetate)