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Application
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FLRF/RNF41 Antibody (A300-048A-T) in WB
Detection of mouse FLRF/RNF41 by western blot. Samples: Whole cell lysate (50 µg) from mouse Raw 264.7cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-FLRF/RNF41 antibody A300-048A-M (lot A300-048A-M-1) used at 1:1000. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A300-048A-T
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Between 250 and 300
Conjugate
Unconjugated
Form
Liquid
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Zebrafish, X. laevis and Orangutan
Target Information
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. Nrdp1, also known as RNF41 (RING finger protein 41), SBBI03 or FLRF, is a 317 amino acid protein that contains one RING-type zinc finger and one SIAH-type zinc finger. Expressed in testis, ovary and prostate, Nrdp1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, Nrdp1 interacts with ErbB-3 and UBPY, thereby targeting them for proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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