PathoDx™ Respiratory Virus Panel Parainfluenza 1 Reagent

Use Thermo Scientific™ Remel™ PathoDx™ Respiratory Virus Panel Parainfluenza 1 Reagent along with PathoDx Respiratory Virus Panel (RVP) kit to perform a direct immunofluorescence test for the qualitative detection of Parainfluenza virus 1 in prepared patient specimens following growth in cell culture. The Parainfluenza viruses and Respiratory Syncytial Virus comprise the most significant viral respiratory pathogens in infants and young children. The clinical diseases caused by Parainfluenza viruses include rhinorrhea, cough, croup (laryngotracheo-bronchitis), bronchiolitis, and pneumonia^1,2.

The Parainfluenza viruses (PIV) belong to the family Paramyxoviridae. The Parainfluenza viruses also possess hemagglutinin, neuraminidase, and cell fusion activities. Four human Parainfluenza virus serotypes have been identified (types 1, 2, 3, and 4). Parainfluenza types 1, 2, and 3 are readily isolated by cell culture while parainfluenza type 4 is more difficult to cultivate^3,4. Type 1 is major cause of croup.

• Ready-to-use – Prepared reagents
• Easy-to-store – Store at 2-8°C
• Easy to interpret – Fluorescence is cytoplasmic, punctated with irregular inclusions.

Parainfluenzae 1 Reagent (Green cap) is one dropper bottle containing 2.0 mL of fluorescein-labeled, purified, specific murine monoclonal antibodies, and Evans blue counterstain in a protein-stabilized buffer solution, with 0.098% sodium azide as a preservative.

Cell culture isolation of parainfluenza viruses is usually done with primary rhesus monkey kidney cells or human kidney cell lines. Cell lines that have been successfully used for propagating parainfluenza viruses include RMK, HEK, LLC-MK2, Vero, A549, and HEp-2⁴.

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