Hypersil™ PREP HS C8 HPLC Columns
Hypersil™ PREP HS C8 HPLC Columns
Thermo Scientific™

Hypersil™ PREP HS C8 HPLC Columns

Use these preparative columns for scale-up purification with high phase loading. They are suitable for all USP-L7 applications.
Catalog NumberLength (Metric)Diameter (Metric)Particle SizeColumn Format
41103-05213050 mm2 mm3 μmPreparative Column, Standard
41103-05463050 mm4.6 mm3 μmPreparative Column, Standard
41103-102130100 mm2 mm3 μmPreparative Column, Standard
41103-104630100 mm4.6 mm3 μmPreparative Column, Standard
41103-152130150 mm2 mm3 μmPreparative Column, Standard
41103-154630150 mm4.6 mm3 μmPreparative Column, Standard
41103-252130250 mm2 mm3 μmPreparative Column, Standard
41103-254630250 mm4.6 mm3 μmPreparative Column, Standard
41105-05213050 mm2 mm5 μmPreparative Column, Standard
41105-05463050 mm4.6 mm5 μmPreparative Column, Standard
41105-059070A50 mm10 mm5 μmPreparative Column, Standard
41105-059270A50 mm20 mm5 μmPreparative Column, Standard
41105-059270XL50 mm25 mm5 μmPreparative Column, Xtended Life
41105-102130100 mm2 mm5 μmPreparative Column, Standard
41105-104630100 mm4.6 mm5 μmPreparative Column, Standard
41105-109070A100 mm10 mm5 μmPreparative Column, Standard
41105-109270A100 mm20 mm5 μmPreparative Column, Standard
41105-109270XL100 mm25 mm5 μmPreparative Column, Xtended Life
41105-152130150 mm2 mm5 μmPreparative Column, Standard
41105-154630150 mm4.6 mm5 μmPreparative Column, Standard
41105-159070A150 mm10 mm5 μmPreparative Column, Standard
41105-159270A150 mm20 mm5 μmPreparative Column, Standard
41105-159270XL150 mm25 mm5 μmPreparative Column, Xtended Life
41105-159370A150 mm30 mm5 μmPreparative Column, Standard
41105-159370XL150 mm30 mm5 μmPreparative Column, Xtended Life
41105-159570A150 mm50 mm5 μmPreparative Column, Standard
41105-159570XL150 mm50 mm5 μmPreparative Column, Xtended Life
41105-252130250 mm2 mm5 μmPreparative Column, Standard
41105-254630250 mm4.6 mm5 μmPreparative Column, Standard
41105-259070A250 mm10 mm5 μmPreparative Column, Standard
41105-259270A250 mm20 mm5 μmPreparative Column, Standard
41105-259270XL250 mm25 mm5 μmPreparative Column, Xtended Life
41105-259370A250 mm30 mm5 μmPreparative Column, Standard
41105-259370XL250 mm30 mm5 μmPreparative Column, Xtended Life
41105-259570A250 mm50 mm5 μmPreparative Column, Standard
41105-259570XL250 mm50 mm5 μmPreparative Column, Xtended Life
41110-018823A8 mm10 mm10 μmGuard Column
41110-019023A20 mm10 mm10 μmGuard Column
41110-019323A30 mm10 mm10 μmGuard 1/16 in.
41110-019323B30 mm10 mm10 μmGuard 1/8 in.
41110-029323A30 mm20 mm10 μmGuard 1/16 in.
41110-029323B30 mm20 mm10 μmGuard 1/8 in.
41110-059070A50 mm10 mm10 μmPreparative Column, Standard
41110-059270A50 mm20 mm10 μmPreparative Column, Standard
41110-059270XL50 mm25 mm10 μmPreparative Column, Xtended Life
41110-109070A100 mm10 mm10 μmPreparative Column, Standard
41110-109270A100 mm20 mm10 μmPreparative Column, Standard
41110-109270XL100 mm25 mm10 μmPreparative Column, Xtended Life
41110-159070A150 mm10 mm10 μmPreparative Column, Standard
41110-159270A150 mm20 mm10 μmPreparative Column, Standard
41110-159270XL150 mm25 mm10 μmPreparative Column, Xtended Life
41110-159370A150 mm30 mm10 μmPreparative Column, Standard
41110-159370XL150 mm30 mm10 μmPreparative Column, Xtended Life
41110-159570A150 mm50 mm10 μmPreparative Column, Standard
41110-159570XL150 mm50 mm10 μmPreparative Column, Xtended Life
41110-259070A250 mm10 mm10 μmPreparative Column, Standard
41110-259270A250 mm20 mm10 μmPreparative Column, Standard
41110-259270XL250 mm25 mm10 μmPreparative Column, Xtended Life
41110-259370A250 mm30 mm10 μmPreparative Column, Standard
41110-259370XL250 mm30 mm10 μmPreparative Column, Xtended Life
41110-259570A250 mm50 mm10 μmPreparative Column, Standard
41110-259570XL250 mm50 mm10 μmPreparative Column, Xtended Life
62 Options
Catalog number 41103-052130
Price (JPY)/ Each
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Length (Metric):
50 mm
Diameter (Metric):
2 mm
Particle Size:
3 μm
Column Format:
Preparative Column, Standard

Get maximum loading for your scale up from analytical to a prep LC method with Thermo Scientific™ Hypersil™ PREP HS C8 reversed phase preparative HPLC column. With similar selectivity to C18 columns and predictable elution order, C8 columns are ideal for analytes with medium hydrophobicity or when a less hydrophobic phase is required to obtain optimum retention. The lower hydrophobicity allows compounds to elute more quickly, yielding faster separations. By providing high surface area particles with a 100Å pore size, and a variety of dimensions including an option for XtendedLife hardware, which improves column lifetime by maintaining a uniform packed bed.

Similar selectivity, less retention than C18 columns

  • Successful retention and separation of moderately hydrophobic analytes.
  • Ideal for fatty acids, which are too hydrophobic for analysis using C18 columns.
  • C8 (USP L7) selectivity - high surface area particle with 100Å pore size.
  • pH stable from 2 to 8.
  • Maximum temperature of 60°C.

Faster separations

  • Higher analytical throughput compared to C18 alkyl chain chemistry.
  • Quicker compound elution due to reduced hydrophobic interactions.

Preparative HPLC Column Hardware Options - based on column inner diameter (i.d.) and column performance needs.

Standard Threaded and Standard Flange Hardware

  • Designed for standard applications, expertly packed and robustly designed to provide versatile products for routine use.
  • Standard threaded hardware for column i.d. < 40mm.
  • Standard flange hardware for column i.d. ≥ 40mm.
  • Standard hardware can be modified on request to be compatible with SFC.

XtendedLife Hardware

  • Improves column lifetime by incorporating an internal Dynamic Axial Compression (DAC) system, ensuring the media bed is continuously packed tightly.
  • Compatible with SFC and is available in dimensions up to 50mm i.d.

Preparative Guards are a proven and cost effective way to extend the lifetime of your prep column. Our preparative guard columns require the use of a preparative guard holder.

Customer Specific Orders

  • If there is a Thermo Scientific stationary phase you are currently using and would like to obtain in a preparative scale not shown or would like to discuss a specific column dimension, we would be happy to discuss your requirements.
  • Please contact your local sales representative for Customer Specific Orders.
  • Custom built columns are not eligible for returns.
Specifications
Column FormatPreparative Column, Standard
Diameter (Metric)2 mm
Length (Metric)50 mm
Max. Pressure5800 psi (400 bar)
Particle Size3 μm
pH2 to 8
Pore Size100 Å
Surface Area350 m²/g
Temperature60°C
USP TypeL7
Stationary PhaseC8
Packing MaterialSpherical, Fully Porous, Ultrapure Silica
Carbon Load7%
Column TypeReversed Phase
EndcappedYes
PhaseReversed Phase
Unit SizeEach