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Catalog Number | Quantity | Packaging |
---|---|---|
454950250 | 25 g | Glass Bottle |
454950010 | 1 g | Glass Bottle |
454950050 | 5 g | Glass Bottle |
General Information
• The cefotaxime sodium salt is a - lactamase considered a third-generation cephalosporin with antibiotic and bactericidal activities
• This compound exerts its biological activity by binding to penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall leading to their inactivation. The inactivation of these proteins affects the cross-linking of peptidoglycan chains required for bacterial cell wall strength and rigidity, resulting in the weakening of cell walls and cell lysis.
Applications
• It is an efficient antibacterial compound that acts against gram-negative bacteria, without activity against gram-positive bacteria such as pseudomonas and penicillin-resistant strains of streptococcus pneumonia
• It has been used for plant cell culture and human cell lines in vitro
• Cefotaxime sodium salt has been used in antibiotic susceptibility testing (AST) methods
• Cefotaxime sodium salt is also used to remove bacteria from Ostreococcus tauri cultures
Literature References
Ali, M. M.; Gaballa, A. S.; Teleb, S. M. Spectroscopic and thermal investigations of charge-transfer complexes formed between cefotaxime sodium drug and various acceptors. Russ. J. Gen. Chem. 2015, 85 (3), 731-745.
Yin, Y.; Bao, Y.; Gao, Z.; Wang, Z.; Liu, D.; Hao, H.; Wang, Y. Solubility of Cefotaxime Sodium in Ethanol + Water Mixtures under Acetic Acid Conditions. J. Chem. Eng. Data 2014, 59 (6), 1865-1871.
Carmine, A.; Brogden, R.; Heel, R.; Speight, T.; Avery, G. Cefotaxime. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1983, 25 (3), 223-289.
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