Methotrexate, Thermo Scientific Chemicals
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Methotrexate, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Methotrexate, Thermo Scientific Chemicals

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100 mg
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Catalog number J63075.03
also known as J63075-03
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Chemical Identifiers
IUPAC Name(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Molecular FormulaC20H22N8O5
InChI KeyFBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILESCN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
Molecular Weight (g/mol)454.45
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SpecificationsSpecification SheetSpecification Sheet
Assay (unspecified)95.0% min.
Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis (RA) and other inflammatory types of arthritis. It is used as an anticancer drug.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents. Protect from light
RUO – Research Use Only

General References:

  1. Allegra et al. Evidence for direct inhibition of de novo protein synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J.Biol.Chem. 1987, 262, (28), 13520-6.
  2. Cronstein, B. N. Low-Dose Methotrexate: A Mainstay in the Treatment of Rheumatoid Arthritis. Pharmacological Reviews . 2005, 57, (2), 163-172.