Intermediate in a useful synthesis of 4,4-dialkyl-2-butenolides, based on reaction with two moles of Grignard reagent, followed by cycloreversion (elimination of furan) to release the double bond.
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Applications
Intermediate in a useful synthesis of 4,4-dialkyl-2-butenolides, based on reaction with two moles of Grignard reagent, followed by cycloreversion (elimination of furan) to release the double bond.
Solubility
Hydrolyzes in water.
Notes
Moisture sensitive. Store away from strong oxidizing agents, water/ moisture.
RUO – Research Use Only
General References:
- Anna Pachuta-Stec; Jolanta Rzymowska; Liliana Mazur; Ewaryst Mendyk; Monika Pitucha; Zofia Rzączyńska. Synthesis, structure elucidation and antitumour activity of N-substituted amides of 3-(3-ethylthio-1,2,4-triazol-5-yl)propenoic acid. European Journal of Medicinal Chemistry. 1988, 44, (9), 3788-3793.
- Hui Chi Huang; Chin I Lin; Abraham K Joseph; Yu Der Lee. Photo-lithographically impregnated and molecularly imprinted polymer thin film for biosensor applications. Journal of Chromatography A. 2004, 1027, (1-2), 263-268.
- Intermediate in a useful synthesis of 4,4-dialkyl-2-butenolides, based on reaction with two moles of Grignard reagent, followed by cycloreversion (elimination of furan) to release the double bond: J. Org. Chem., 47, 3953 (1982); Tetrahedron Lett., 24,1929 (1983):
- For a review of cycloreversion reactions in organic synthesis, see: Synthesis, 121 (1985).