Search Thermo Fisher Scientific
- Order Status
- Quick Order
-
Don't have an account ? Create Account
Search Thermo Fisher Scientific
The GeneBLAzer™ MC2R CHO-K1 DA (Division Arrested) cells contain the human melanocortin-2 receptor (MC2R), (Accession No. NM_000529.1) and the Melanocortin-2 receptor accessory protein (MRAP), (Accession No. NM_178817.3) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. No. K1129) contain a beta-lactamase (bla) reporter gene under control of the cAMP Response Element (CRE).
The MC2R-CHOK1 DA cells are functionally validated for Z'-factor and EC50 concentrations of ACTH 1-24. In addition, MC2R-CRE-bla-CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary in the Manuals and Brochures section. DA cells are irreversibly division arrested using a low-dose treatment of Mitomycin C, and have no apparent toxicity or change in cellular signal transduction.