Thermo Scientific Pierce TMEA is a trifunctional crosslinker containing three reactive maleimide groups to enable three-way conjugation and polymerization of sulfhydryl-containing molecules.
Features of Thermo Scientific Pierce TMEA:
• Reactive groups: maleimide (on three termini) • Reactive towards: sulfhydryl groups • 3-way, sulfhydryl-to-sulfhydryl crosslinker; tris (2-maleimidoethyl) amine, composed of three maleimide groups on short spacer arms • Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers • Noncleavable • Useful for the preparation of trimeric complexes of cysteine-containing peptides and other sulfhydryl-containing compounds • Core molecule for the construction of dendritic polymers
Product References: Crosslinker Application Guide -- search for recent literature references for this product